Uses non-negative least squares (NNLS) to decompose bulk gene expression
into cell-type-specific expression estimates, given known cell-type fractions.
Usage
estimate_expression_profiles(bulk_expr, cell_fracs)
Arguments
- bulk_expr
A numeric matrix of bulk gene expression with genes as rows
and samples as columns.
- cell_fracs
A numeric matrix of cell-type fractions with samples as rows
and cell types as columns. Row names must match column names of bulk_expr.
Value
A named list of matrices, one per cell type. Each matrix has samples
as rows and genes as columns, containing the estimated expression
contribution of that cell type.
