Build a GSEA-Derived Signature Label for a Cell Subgroup

Runs fgsea on ranked genes and creates a subgroup signature name based on the top positively enriched pathway.

Usage

create_gsea_signature(gene_scores, cell_type, pathways = NULL, plot = FALSE)

Arguments

gene_scores

Data frame of ranked scores (as produced by compute_data_driven_rank()).

cell_type

Character label used as prefix in the generated signature name.

pathways

Optional named list of pathways (pathway -> genes). If NULL, Hallmark pathways from msigdbr are used.

plot

Logical; if TRUE, save a top-20 fgsea dot plot in Results/.

Value

A list with two elements: [[1]] generated signature name, [[2]] a named list of enriched pathways.