Student's t-test for cell group comparisons

Performs a Student's t-test comparing cell group scores between two groups of a binary trait. Significant features are plotted as boxplots and saved as PDF files in the "Results/" directory.

Usage

scores.ttest(scores, coldata, trait, pval = 0.05)

Arguments

scores

A list or matrix of cell group scores. When a list, the first element must be a data frame or matrix of scores (samples x features).

coldata

A data frame containing sample-level annotations including the trait to test.

trait

Character. Name of the column in coldata used as the grouping variable.

pval

Numeric. P-value threshold for significance (default = 0.05).

Value

A list containing only significant cell groups after the t-test. Returns NULL if no significant groups are found.